Optimising the Aerodynamic Performance of Spray Dried mRNA Lipoplexes in Mannitol or Lactose Matrix

MEGGLE Excipients and the University of Kiel have joined forces to shed light on this interesting topic. 

Introduction:

• Many respiratory pathogens enter the body through the respiratory tract, the lungs and the mucosal immune system are promising targets for therapeutic interventions.
• Liquid vaccines face the risk of chemical degradation and physical instability
  -> Solid formulations can secure stability without challenging storage conditions. Since spray drying offers continuous manufacturing with high
  production capacity, we chose spray drying as production technique.

Objective:

Formulation of an Inhalable Dry Powder Platform for mRNA Therapeutics

Authors:

Many thanks to the authors for this exciting publication.

Jana Schembera¹, Ricarda Leister², Constanze Müller², Regina Scherließ¹
1Department of Pharmaceutics and Biopharmaceutics, Kiel University, Germany
2Meggle GmbH & Co. KG, Wasserburg am Inn, Germany

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