MEGGLE Excipients + University of Kiel | Scientific Paper: The role of mechanical properties in DPI carrier

The role of mechanical properties in DPI carriers

MEGGLE Excipients and the University of Kiel have joined forces to shed light on this interesting topic. 


  • Aerodynamic performance of interactive blends depends on mixing time/energy
  • Leading hypothesis assumes the effect of so called press-on-forces (i.e deformation of particles during mixing)
  • Mechanical properties of particles should predict the behaviour of fine particle fraction (FPF) with respect to mixing time if the hypothesis holds true


Verify the relationship between mechanical properties and FPF

  1. Create model carriers with varying plasticity
  2. Evaluate their mechanical properties
  3. Investigate aerodynamic performance
  4. Link mechanical properties and aerodynamic performance


Many thanks to the authors for this exciting publication.

Zeredescht Majid1, Ricarda Leister², Constanze Mueller², Regina Scherließ1
1 Department of Pharmaceutics and Biopharmaceutics, Kiel University, Gutenbergstr. 76, 24118 Kiel, Germany
2 Meggle GmbH & Co.KG, Megglestr. 6-12, 83512 Wasserburg am Inn, Germany

If the topic sounds interesting to you, you are welcome to download the publications.

MEGGLE Experts in Excipients

The role of mechanical properties in DPI carriers