Successful power preparation
MEGGLE has it.
The right lactose product for powder preparations – Capsule and Sachet fillings
Although tablets account by far for the majority of solid oral dosage forms, powder preparations, such as capsules and sachets, present viable options to the developer.
Lactose: Suitable for Capsule filling
Traditionally capsules made up of gelatin have been used, whereas lactose is more than suitable as capsule filler, based on its limited interaction with gelatin capsules, preserving the capsule integrity over time. This has clearly not changed for Hydroxypropylmethylcellulose (HMPC) capsules, which have gained a lot of popularity. Capsules are of special interest for early stage developments and clinical trials medication, where on a final formulation has not been decided yet.
Furthermore, patient centric medicines for children and elderly, which allow for circumventing impaired tablet-swallowing can be developed by the use of capsule and sachets. Life cycle management also acknowledges these kinds of dosage forms, which may lead to gaining market share for well-established drugs, which have been around for a while. When developing a powder preparation, processability of the final powder blend as well as content uniformity and little to no powder segregation is imperative to a successful development.
Important: Consistent functionality
MEGGLE has decided to contribute to these needs in a meaningful way by providing a range of lactose grades which differ in particle size distribution as well as bulk density. Both parameters are essential to a successful development. If chosen correctly, content uniformity issues may be a minor obstacle or do not bother at all. In order to provide consistent functionality MEGGLE has implemented a rigorous quality system, which exceeds current Good Manufacturing Practice (GMP) requirements by far.
Improve products: Co-operation with machine manufacturers
As MEGGLE aims to achieve ultimate customer satisfaction, it has partnered with leading capsule-filling-machine-manufactures in order to provide expertise from both ends, material and processing. By partnering with these companies, MEGGLE is also able to tweak and improve its products, which leads to improved off-the-shelf products but gives the customers also the option to choose a tailor-made grade for even better performance.
MEGGLE’s lactose grades suitable for powder preparation e.g. capsule and sachet filling are available under the trade names PrismaLac® 40, CapsuLac® 60, SacheLac® 80 and SpheroLac® 100
Information / Sample request:
MEGGLE has it.
The right lactose product for powder preparations – Capsule and Sachet fillings
Although tablets account by far for the majority of solid oral dosage forms, powder preparations, such as capsules and sachets, present viable options to the developer.
Lactose: Suitable for Capsule filling
Traditionally capsules made up of gelatin have been used, whereas lactose is more than suitable as capsule filler, based on its limited interaction with gelatin capsules, preserving the capsule integrity over time. This has clearly not changed for Hydroxypropylmethylcellulose (HMPC) capsules, which have gained a lot of popularity. Capsules are of special interest for early stage developments and clinical trials medication, where on a final formulation has not been decided yet.
Furthermore, patient centric medicines for children and elderly, which allow for circumventing impaired tablet-swallowing can be developed by the use of capsule and sachets. Life cycle management also acknowledges these kinds of dosage forms, which may lead to gaining market share for well-established drugs, which have been around for a while. When developing a powder preparation, processability of the final powder blend as well as content uniformity and little to no powder segregation is imperative to a successful development.
Important: Consistent functionality
MEGGLE has decided to contribute to these needs in a meaningful way by providing a range of lactose grades which differ in particle size distribution as well as bulk density. Both parameters are essential to a successful development. If chosen correctly, content uniformity issues may be a minor obstacle or do not bother at all. In order to provide consistent functionality MEGGLE has implemented a rigorous quality system, which exceeds current Good Manufacturing Practice (GMP) requirements by far.
Improve products: Co-operation with machine manufacturers
As MEGGLE aims to achieve ultimate customer satisfaction, it has partnered with leading capsule-filling-machine-manufactures in order to provide expertise from both ends, material and processing. By partnering with these companies, MEGGLE is also able to tweak and improve its products, which leads to improved off-the-shelf products but gives the customers also the option to choose a tailor-made grade for even better performance.
MEGGLE’s lactose grades suitable for powder preparation e.g. capsule and sachet filling are available under the trade names PrismaLac® 40, CapsuLac® 60, SacheLac® 80 and SpheroLac® 100